NIPT determines the number of 21, 13 and 18 chromosomes, and can detect the sex.
The following disorders cannot always be detected with NIPT:
- mosaicism of chromosome 21, and
- small abnormalities (deletions or duplications) of chromosome 21.
Molecular monogenic abnormalities (such as cystic fibrosis and fragile X) cannot be detected with NIPT yet.