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What is genetics?
DNA
Introduction DNA
The human genome
Nuclear DNA
Mitochondrial DNA
Genes
What are genes?
Information and nonsense?
Gene expression
Chromosomes
Book chapters
Autosomes
Sex chromosomes
DNA transfer
Inherited
Congenital or acquired
Genetic variation
At chromosome level
Deletion
Duplication
Inversion
Translocation
Marker chromosome
Fragile sites and break points
At DNA level
Repeats
Deletion, duplication and insertion
Point mutation
Inheritance
Monogenic inheritance
Autosomal dominant disorders
Autosomal recessive disorders
Sex-linked disorders
Mitochondrial inheritance
Multifactorial inheritance
Degrees of severity
Mosaicism
Variable expression and penetrance
Late-onset genetic disorders
Who are we?
We are here for you
Our mission
Patient is key
For our professionals
Part of UZ Brussel
Our team
Our partners
In own house
Partners
Interdisciplinary teams
Medical ethics commitee
Satellite consultations
Outside UZ Brussel
Co-operating hospitals
University partners
The seven other centres for medical genetics in Belgium
BeSHG – Belgian Society of Human Genetics
The College of Medical Genetics
Organisations and databases
Organisations
Databases
Press
Recent
Archive
Consultations
Clinic timetable
What can we offer you?
What is your question?
Aim of consultations
Scope for the patient
For which disorders?
General hereditary problems
Problems regarding reproduction and heritability
Family cancer*
Specific hereditary problems regarding one organ
Specific hereditary disease
Follow-up of children born after assisted reproductive treatment
Psychosocial counselling
From information and testing to diagnosis
Questions and testing
Patient's decision
Diagnosis
Timing
Treatment and guidance
Inform
Preventive guidance
Support
Types of consultations
Psychosocial
Before, during and afterwards
PGD counselling
Preconceptual
Pre-implantation
Prenatal
What is Down syndrome ?
Testing for Down syndrome
Am I obliged to have a risk calculation for trisomy 21?
Choice between a NIPT, chorionic villus sampling and an amniocentesis
Difference between the combined test and NIPT
Postnatal
Baby or child
Adult with childwhish
Adult predictive
Following up ART babies
Prenatal examinations
Combined test
How does the test work?
How reliable is the combined test?
What are the risks for the baby?
When is the result of the combined test available?
How sensitive is the combined test?
How much does the combined test cost?
NIPT
How sensitive is NIPT?
What are the risks for my baby?
When is NIPT applied?
Who does not come into consideration for NIPT?
What are the limitations of NIPT?
What are the possible results of NIPT?
When is the NIPT result available?
How much does NIPT cost?
Chorionic villus tissue
Amniocentesis
Umbilical puncture
Tests on miscarriage tissue
Postnatal analyses
Laboratories
Available genetic tests
Information on PGD testing
Overview of PGD tests available
Logistic laboratory services
Quality
Laboratory secretariat
Handling analysis requests
Sample management
Checking samples and distributing them to laboratories
Preparing samples for use
BRIGHTcore
Executive laboratories
Scope of the tests
Biochemistry lab
Lysosomal storage diseases
Biochemical technique
Cytogenetics lab
Pre-treatment conventional chromosomal tests
Conventional karyotyping
Fluorescence In Situ Hybridisation - FISH
Molecular karyotyping - CGH-array
Molecular genetics lab
Mutations and consequences of mutations
The basis: PCR
The analysis methods
PGD lab
PGD chromosome testing: array CGH or FISH
PGD DNA testing: STR-analysis or SNP-array
Genetic tests available
Genome or exome sequencing
PGD
PGD: what: why and for whom?
Who is it for?
Why PGD?
Reliability
Safety
Chances of success
The preliminary process
Contact
Consultations
Consultation with the geneticist
Consultation with the fertility gynaecologist
Psychological consultation
Informative discussions with the counselor
Travelling during treatment
The PGD test
Avoid spontaneous pregnancy
What type of PGD test?
How long before test results?
Treatment: ICSI
Before you start
The counsellor interview
Scheduling and starting treatment
IVF/ICSI in a nutshell
The course of hormonal stimulation
The egg retrieval
In the laboratory
Embryo transfer
Freezing embryos
Monitoring the possible pregnancy
Postnatal follow-up
PGS
Genetic embryo analysis
For which chromosomes?
The value of PGS
Practical
Appointments
Informed consents
Destiny of supernumerary embryos
The financial aspect
Guide
How to find us?
Directions
Find your way to, and around, the CMG
Traffic
Guide for patients
Appointment | Registration
Before your appointment
Registering at the hospital
Cancelling an appointment
Prenatal - Practical
Preconceptual tests
Prenatal tests
Delivery and/or discussion of the results
Processing
Financial
Test results
Processing time required for chromosome, molecular and biochemical tests
How long for a PGD test result?
In practice
Financial
Belgian patients with health insurance
Patients without Belgian health insurance
Pay consultation on the day
Laboratory services
PGD patients
Prices & NHS-coverage
Documents
Informed consents
Questionnaires
Family tree to complete
Brochures
FAQ
Why do you need samples from familiy members to develop a test?
Why can you not tell in advance how long it will take to develop the test?
Glossary
Guide for professionals
Request forms
Clinical checklists
Instructions
Instructions for delivering samples
How to deliver samples to us?
Acceptance criteria
General request and acceptance criteria
Lab analysis delayed
Guidelines | Legislation
Guidelines
Legislation
Referring patients
Which genetic analyses?
Research
Scientific research
Current projects
The epigenetic stability and the safety of assisted reproduction techniques
Research into mitochondrial DNA
Research into ART children
Genetic causes of male infertility
Unravelling the genetic molecular cause of the congenital cardiac arrhythmia, the Brugada syndrome
Malformations of cortical development: identification of novel genes and their function
Seminars
Seminars - subscribe
Seminars - archive
Scientific publications
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2015
2014
2013
2012
2011
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2009
2008
2007
2006
2005
2004
2003
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